The name "appleseed" has several hidden meanings. In the original manga, it was the term of a worldwide environmental decontamination plan initiated by the Orion Group after the nuclear fallout of World War III, as well as an inside joke in Book Two, Prometheus Unbound (see the FAQ for more on this).
-- DID YOU KNOW? -- In Japanese, Appleseed is pronounced as Appurushido.
GETTING TO KNOW THE SERIES